Beilstein J. Org. Chem.2020,16, 1863–1868, doi:10.3762/bjoc.16.153
, hydrolysis of the ester with a mixture of HBr and AcOH gave 2-(perfluorophenyl)aceticacid in a good preparative yield of 63%. A significant advantage of this new approach to 2-(perfluorophenyl)aceticacid is that handling toxic substances such as cyanides and perfluorinated benzyl halides is avoided
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Keywords: decarboxylation; fluorinated aromatic compounds; hydrolysis of esters; 2-(perfluorophenyl)aceticacid; 2-(perfluorophenyl)malonic acid; Introduction
2-Phenylmalonic acid (1) and its esters are useful and versatile intermediates in the synthesis of many practically important compounds, e.g
malonic acid 2 was isolated from the reaction mixtures; the main part of the original material was recovered. In some experiments, variable amounts of 2-(perfluorophenyl)aceticacid (12) were obtained after acidification of the basic solution. Moreover, noticeable decomposition of 3 was observed along